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Nanomedicine in Therapeutic Intervention of Tuberculosis Meningitis

Author(s): Anil K. Sharma, Rohit Sharma, Ramesh Jhorar, Raman Kumar.

Graphical Abstract:


Abstract:

Nanotechnology has shown tremendous scope in healthcare offering numerous possibilities to significantly improve diagnosis of many dreadful diseases including Tuberculosis (MTB). Nanomedicine has made the current drug regimen more effective against tuberculosis particularly tuberculosis meningitis with attributes like sustained release, increased half life, higher drug concentrations at target sites, reduced toxicity and lesser side effects. However because of the severity of the disease, there is a strong urge to develop better approaches with some concomitant regimens using nano-particles to diagnose, treat and manage tuberculosis meningitis (TBM) patients. The rate of drug resistance is also reportedly higher in case of TBM, which may further reduce the patient compliance and therapeutic failure of the current regimen. Hence there is an urgent need to develop effective ways to counter TBM. The current review highlights some of the evolving strategies in the field of nanomedicine offering promising alternatives to the existing TBM regimens. The study also emphasizes upon the need to design more effective biocompatible and biodegradable nanocarriers which can effectively cross the blood brain barrier to counter TBM.

Keywords: Blood-brain barrier (bbb), drug regimen, nanocarriers, nanomedicine, Tuberculosis meningitis (TBM).

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2015
Page: [15 - 22]
Pages: 8
DOI: 10.2174/1573413710666141016000110
Price: $58