Abstract
The process of analysing metabolic pathways mathematically in systems biology requires accurate parameters which represent the simulated in-vivo processes. Differential Evolution algorithm (DE) has been provenable to outperform other estimation algorithms, and has been used to achieve an accurate estimation of the required parameters. The total number of DE-variants has increased recently, which makes researchers face difficulties in obtaining complete overview of current DE-variants. To provide a holistic view to the area of mathematical modelling in System Biology, through this paper, we present an overview of modelling methods, parameter estimation by utilizing DE-variants to analyse metabolic pathways, and exiting pathway simulation software.
Keywords: Differential evolution, modelling, system biology.
Current Bioinformatics
Title:A Review on Modelling Methods, Pathway Simulation Software and Recent Development on Differential Evolution Algorithms for Metabolic Pathways in Systems Biology
Volume: 9 Issue: 5
Author(s): Chuii Khim Chong, Mohd Saberi Mohamad, Safaai Deris, Mohd Shahir Shamsir, Yee Wen Choon and Lian En Chai
Affiliation:
Keywords: Differential evolution, modelling, system biology.
Abstract: The process of analysing metabolic pathways mathematically in systems biology requires accurate parameters which represent the simulated in-vivo processes. Differential Evolution algorithm (DE) has been provenable to outperform other estimation algorithms, and has been used to achieve an accurate estimation of the required parameters. The total number of DE-variants has increased recently, which makes researchers face difficulties in obtaining complete overview of current DE-variants. To provide a holistic view to the area of mathematical modelling in System Biology, through this paper, we present an overview of modelling methods, parameter estimation by utilizing DE-variants to analyse metabolic pathways, and exiting pathway simulation software.
Export Options
About this article
Cite this article as:
Chong Khim Chuii, Mohamad Saberi Mohd, Deris Safaai, Shamsir Shahir Mohd, Choon Wen Yee and Chai En Lian, A Review on Modelling Methods, Pathway Simulation Software and Recent Development on Differential Evolution Algorithms for Metabolic Pathways in Systems Biology, Current Bioinformatics 2014; 9 (5) . https://dx.doi.org/10.2174/157489360905141014154242
DOI https://dx.doi.org/10.2174/157489360905141014154242 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Myogenic Tone as a Therapeutic Target for Ischemic Stroke
Current Vascular Pharmacology Imaging of Neurotrauma in Acute and Chronic Settings
Current Neuropharmacology Oxidative Stress Induced Mitochondrial DNA Deletion as a Hallmark forthe Drug Development in the Context of the Cerebrovascular Diseases
Recent Patents on Cardiovascular Drug Discovery Trends in Medical Image Compression
Current Medical Imaging ACKNOWLEDGEMENTS TO THE REVIEWERS
Current Cardiology Reviews AMP-activated Protein Kinase As a Target For Pathogens: Friends Or Foes?
Current Drug Targets Subject Index to Volume 10
Current Pharmaceutical Design Anti-IL-1 β Therapies
Recent Patents on DNA & Gene Sequences ACKNOWLEDGEMENTS TO REVIEWERS
Current Vascular Pharmacology Current Medical and Surgical Stroke Prevention Therapies for Patients with Carotid Artery Stenosis
Current Neurovascular Research Transcription Factors in Heart: Promising Therapeutic Targets in Cardiac Hypertrophy
Current Cardiology Reviews Patent Annotations
Recent Patents on Anti-Infective Drug Discovery Atrial Fibrillation and Chronic Kidney Disease in Hypertension: A Common and Dangerous Triad
Current Vascular Pharmacology Emerging Therapies Targeting Tumor Vasculature in Multiple Myeloma and other Hematologic and Solid Malignancies
Current Cancer Drug Targets Pathophysiology of the Vascular Wall and its Relevance for Cerebrovascular Disorders in Aged Rodents
Current Neurovascular Research Use of Chou’s 5-steps Rule to Study the Effect of Cereal Dietary Protein on Liver and Coronary Heart Disease Prevention
Current Nutrition & Food Science Risk Factors for Development of Heart Failure
Current Cardiology Reviews PKC Delta and Epsilon in Drug Targeting and Therapeutics
Recent Patents on DNA & Gene Sequences Jaridonin, a Novel Ent-Kaurene Diterpenoid from Isodon rubescens, Inducing Apoptosis via Production of Reactive Oxygen Species in Esophageal Cancer Cells
Current Cancer Drug Targets Embryonic Stem Cell-Based Screen for Small Molecules: Cluster Analysis Reveals Four Response Patterns in Developing Neural Cells
Current Medicinal Chemistry