Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University


A Review on Modelling Methods, Pathway Simulation Software and Recent Development on Differential Evolution Algorithms for Metabolic Pathways in Systems Biology

Author(s): Chuii Khim Chong, Mohd Saberi Mohamad, Safaai Deris, Mohd Shahir Shamsir, Yee Wen Choon, Lian En Chai.


The process of analysing metabolic pathways mathematically in systems biology requires accurate parameters which represent the simulated in-vivo processes. Differential Evolution algorithm (DE) has been provenable to outperform other estimation algorithms, and has been used to achieve an accurate estimation of the required parameters. The total number of DE-variants has increased recently, which makes researchers face difficulties in obtaining complete overview of current DE-variants. To provide a holistic view to the area of mathematical modelling in System Biology, through this paper, we present an overview of modelling methods, parameter estimation by utilizing DE-variants to analyse metabolic pathways, and exiting pathway simulation software.

Keywords: Differential evolution, modelling, system biology.

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Article Details

Year: 2014
Page: [509 - 521]
Pages: 13
DOI: 10.2174/157489360905141014154242
Price: $58