Objective: To reveal the cutoff point and influencing factors in the dynamic change in phenotypic group in patients
with stable angina pectoris (SAP) after Xinxuekang capsule treatment.
Methods: Five hundred and seventy-six SAP patients were randomly assigned to receive Xinxuekang (XXK) capsules or
Compound Danshen (CDS) tablets for 8 weeks. Global similarity degree analysis and nonlinear mixed effects modeling
(NONMEM) were employed to reveal the cutoff points and influencing factors in dynamic changes in the SAP phenotypic
group. The phenotypic group was defined as the six phenotypes in SAP, including angina, choking sensation in the chest,
palpitations, dark purple lips, ecchymosis on the tongue, and fine-choppy pulse, which were quantitatively evaluated on
Days 0, 14, 28, 42, and 56.
Results: Variation in the six individual phenotypes and distribution of the SAP phenotypic profile were similar between the
two experimental groups, but cutoff points for changes in the SAP phenotypic group were 7.28 and 10.73 weeks in XXK and
CDS groups, respectively. Degree of severity of SAP as well as study site significantly affected the tendency for change in
the SAP Xueyu Zheng in both XXK and CDS treatment groups. Different Chinese patent drugs affected the tendency for
change in phenotypic group in patients with SAP. XXK was superior to CDS in controlling a clinical phenotypic group.
Conclusion: Based on global similarity degree analysis and NONMEM, the cutoff point and influencing factors in phenomic
variation of SAP may be determined, to improve the development and modification of treatment regimens.