Novel Anti-inflammatory Interleukin-35 as an Emerging Target for Antiatherosclerotic Therapy

Author(s): Yuri V. Bobryshev , Igor A. Sobenin , Alexander N. Orekhov , Dimitry A. Chistiakov .

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 9 , 2015

Abstract:

Atherosclerosis has been widely recognized as a slow progressing inflammatory disease of the aorta and other large caliber arterial vessels. Accumulating evidence suggest that interleukin (IL)-35 can represent an attractive target for future anti-atherosclerotic therapy due to several atheroprotective properties. First, immunosuppressive and anti-inflammatory activity of this cytokine could be beneficial against vascular inflammation. Second, IL-35 can suppress a variety of T cells including proinflammatory Th1 and Th17 cells and probably dendritic cells. Third, IL-35 supports proliferation of regulatory T cells (Tregs), increases their inhibitory function, and induces a new set of Tregs called inducible IL-35-producing Tregs (iTr35 cells). Fourth, this cytokine promotes production of antiinflammatory cytokines such as IL-10 and down-regulates expression of proinflammatory cytokines such as IL-17. Finally, IL-35 is inducible. The fact that IL-35 could be induced by simple compounds such as chemical chaperons may provide advances in developing new efficient strategies for treatment of atherosclerosis. However, it is necessary to test IL-35-inducing factors in order to understand mechanisms of induction and then select the most optimal one. Probably, constructing of humanized antibodies that mimic IL-35 function may provide benefits for advanced atheroprotective therapy.

Keywords: Inflammation, interleukin-35, atherosclerosis, atherogenesis, arteries, anti-atherosclerotic therapy.

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Article Details

VOLUME: 21
ISSUE: 9
Year: 2015
Page: [1147 - 1151]
Pages: 5
DOI: 10.2174/1381612820666141014123810
Price: $58

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