Dendritic Cells: A Double-Edge Sword in Atherosclerotic Inflammation

Author(s): Dimitry A. Chistiakov , Igor A. Sobenin , Alexander N. Orekhov , Yuri V. Bobryshev .

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 9 , 2015

Abstract:

Functional heterogeneity of dendritic cells (DCs) observed in atherosclerosis suggest for their complex and multifaced role in the pathogenesis of atherosclerotic disease. A delicate balance between anti-inflammatory and pro-inflammatory mechanisms drives atherogenesis, and local microenvironment triggers the actual involvement of DCs in atherosclerosis-associated inflammation. Responding to microenvironment stimuli, DCs contribute to atherogenesis in both ways being involved in supporting proatherogenic vascular inflammation and by suppressing inflammatory responses via induction of self-tolerogenic properties and regulatory T cells (Tregs). The local microenvironment and extrinsic stimuli influence DC phenotype and hence could control the phenotypic switch toward inflammation or tolerance.

Keywords: Atherosclerosis, arteriosclerosis, arteries, inflammation, dendritic cells, plasmacytoid dendritic cells.

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Article Details

VOLUME: 21
ISSUE: 9
Year: 2015
Page: [1118 - 1123]
Pages: 6
DOI: 10.2174/1381612820666141013162528
Price: $58

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