Regulatory T Cells and Tolerogenic Dendritic Cells as Critical Immune Modulators in Atherogenesis

Author(s): Naoto Sasaki, Tomoya Yamashita, Kazuyuki Kasahara, Masafumi Takeda, Ken-ichi Hirata.

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 9 , 2015

Abstract:

Innate and adaptive immunity has been shown to be critically involved in the pathogenesis of atherosclerosis. In particular, immune suppression mediated by regulatory T cells (Tregs) or tolerogenic dendritic cells (DCs) serves as a vital mechanism for regulating pathogenic chronic inflammation in atherogensis, suggesting that promotion of endogenous regulatory immune responses could be a possible therapeutic approach to suppress atherosclerotic disease. In this review, we discuss the possible role of Tregs and tolerogenic DCs in the prevention of atherosclerosis and the promising strategies to prevent or cure atherosclerotic disease by modulating regulatory immune responses mediated by these suppressor cells.

Keywords: Atherosclerosis, immune system, inflammation, regulatory T cells, tolerogenic dendritic cells.

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Article Details

VOLUME: 21
ISSUE: 9
Year: 2015
Page: [1107 - 1117]
Pages: 11
DOI: 10.2174/1381612820666141013142518
Price: $58

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