The Synthesis of Risedronic Acid and Alendronate Applying Phosphorus Oxychloride and Phosphorous Acid in Methanesulfonic Acid

Author(s): Alajos Grun, Rita Kovacs, Sandor Garadnay, Istvan Greiner, Gyorgy Keglevich.

Journal Name: Letters in Drug Design & Discovery

Volume 12 , Issue 4 , 2015

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Graphical Abstract:


The synthesis of risedronic acid and alendronate from 3-pyridylacetic acid and γ- aminobutyric acid, respectively, using phosphorus oxychloride and phosphorous acid as the P-reagents and methanesulfonic acid as the solvent was optimized, and the role of phosphorus oxychloride and phosphorous acid in the reaction was clarified.

Keywords: Alendronate, mechanism, optimization, phosphorus oxychloride, phosphorous acid, risedronic acid, synthesis.

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Article Details

Year: 2015
Page: [253 - 258]
Pages: 6
DOI: 10.2174/1570180811666141010220427

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