Amyotrophic Lateral Sclerosis: A Genetic Point of View

Author(s): C. Carlesi, E. Caldarazzo Ienco, M. Mancuso, G. Siciliano.

Journal Name: Current Molecular Medicine

Volume 14 , Issue 8 , 2014

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Abstract:

In the last twenty years the rapid advances in neurogenetic have revolutionized not only the molecular, pathological, inheritance but also the clinical concept of ALS.

Here we review the current genetic breakthrough in familial and sporadic ALS, considering how this knowledge has allowed widening of the scenario on the possible pathogenic disease mechanisms and better understanding of the relationship between the genetic, pathological and clinical subtypes.

Keywords: Amyotrophic Lateral Sclerosis, dementia, genetic tests, GWA, mutation, phenotype, WES.

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Article Details

VOLUME: 14
ISSUE: 8
Year: 2014
Page: [1089 - 1101]
Pages: 13
DOI: 10.2174/1566524014666141010155822
Price: $58

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