Abstract
MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression by targeting mRNAs and leading to either translation repression or RNA degradation. miRNAs have fundamental effects in the regulation of intracellular processes, and their importance during malignant transformation and metastasis is becoming increasingly well understood. The epithelial-mesenchymal transition (EMT), which reprograms tumor cells transcription, has been highlighted as a powerful process in tumor invasion, metastasis and tumorigenicity. In recent years, many studies have significantly enhanced our knowledge of EMT by the characterization of miRNAs that influence the signaling pathways and downstream events that define EMT on a molecular level. In this review, we detail the miRNAs and signal transduction pathways involved in the EMT process and demonstrate their importance in the study of cancer progression. We believe that this information will improve prognostication and reveal new opportunities for therapeutic intervention.
Keywords: EMT, miRNA, miR-200 family, P53, TGFβ signaling.
MicroRNA
Title:MicroRNAs Regulate the Epithelial to Mesenchymal Transition (EMT) in Cancer Progression
Volume: 3 Issue: 2
Author(s): Yang Hu and Hua Tang
Affiliation:
Keywords: EMT, miRNA, miR-200 family, P53, TGFβ signaling.
Abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression by targeting mRNAs and leading to either translation repression or RNA degradation. miRNAs have fundamental effects in the regulation of intracellular processes, and their importance during malignant transformation and metastasis is becoming increasingly well understood. The epithelial-mesenchymal transition (EMT), which reprograms tumor cells transcription, has been highlighted as a powerful process in tumor invasion, metastasis and tumorigenicity. In recent years, many studies have significantly enhanced our knowledge of EMT by the characterization of miRNAs that influence the signaling pathways and downstream events that define EMT on a molecular level. In this review, we detail the miRNAs and signal transduction pathways involved in the EMT process and demonstrate their importance in the study of cancer progression. We believe that this information will improve prognostication and reveal new opportunities for therapeutic intervention.
Export Options
About this article
Cite this article as:
Hu Yang and Tang Hua, MicroRNAs Regulate the Epithelial to Mesenchymal Transition (EMT) in Cancer Progression, MicroRNA 2014; 3 (2) . https://dx.doi.org/10.2174/2211536603666141010115102
DOI https://dx.doi.org/10.2174/2211536603666141010115102 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
Call for Papers in Thematic Issues
Modulatory Roles of Non-coding RNAs in cancer therapy
This thematic issue aims to elucidate the most recent research on ncRNAs in CRCs and discuss the importance and difficulties that may arise in applying this tool on a regular clinical basis.read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chemopreventive Properties of Indole-3-Carbinol, Diindolylmethane and Other Constituents of Cardamom Against Carcinogenesis
Recent Patents on Food, Nutrition & Agriculture Clinical Experience with Therapeutic Vaccines Designed for Patients with Hepatitis
Current Pharmaceutical Design Targeting the RAS Signaling Pathway in Malignant Hematologic Diseases
Current Drug Targets Drug-Delivery Systems of Green Tea Catechins for Improved Stability and Bioavailability
Current Medicinal Chemistry Novel Nanocolloidal Carriers for Noninvasive Vaccine Delivery
Current Drug Therapy Role of Alterations in the Apoptotic Machinery in Sensitivity of Cancer Cells to Treatment
Current Pharmaceutical Design β-Catenin/TCF-4 Signaling Regulates Susceptibility of Macrophages and Resistance of Monocytes to HIV-1 Productive Infection
Current HIV Research Pediatric Differentiated Thyroid Cancer: When to Perform Conservative and Radical Surgery
Current Pediatric Reviews Antitumor Activity of Cyclodextrin-based Supramolecular Platinum Prodrug In vitro and In vivo
Letters in Drug Design & Discovery Piecing the Fragments Together: Dynamical Insights into the Enhancement of BRD4-BD1 (BET Protein) Druggability in Cancer Chemotherapy Using Novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one Derivatives
Current Pharmaceutical Biotechnology MicroRNA and Bone Tumor: To Up Date
Current Signal Transduction Therapy Tumor Escape from Immune Response: Mechanisms and Targets of Activity
Current Drug Targets Disulfiram, and Disulfiram Derivatives as Novel Potential Anticancer Drugs Targeting the Ubiquitin Proteasome System in Both Preclinical and Clinical Studies
Current Cancer Drug Targets Rhein Derivatives, A Promising Pivot?
Mini-Reviews in Medicinal Chemistry Roles of Natural Compounds from Medicinal Plants in Cancer Treatment: Structure and Mode of Action at Molecular Level
Medicinal Chemistry Metabolic Transformation and Mechanism of Action of Mononitroso Caffeidine- A New Interpretation
Endocrine, Metabolic & Immune Disorders - Drug Targets Anal Cancer: Focus on HIV-Positive Patients in the HAART Era
Current HIV Research Transmission and Immunopathogenesis of FIV in Cats as a Model for HIV
Current HIV Research Irreversible LSD1 Inhibitors: Application of Tranylcypromine and Its Derivatives in Cancer Treatment
Current Topics in Medicinal Chemistry Nanomaterials and Stem Cell Differentiation Potential: An Overview of Biological Aspects and Biomedical Efficacy
Current Medicinal Chemistry