Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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Chalcones Incorporated Pyrazole Ring Inhibit Proliferation, Cell Cycle Progression, Angiogenesis and Induce Apoptosis of MCF7 Cell Line

Author(s): Magda F. Mohamed, Mervat S. Mohamed, Mohamed M. Fathi, Samia A. Shouman, Ismail Abdelshafy Abdelhamid.

Graphical Abstract:


Abstract:

A Series of chalcone derivatives containing pyrazole ring was prepared and their cytotoxicity against different human cell lines, including breast (MCF-7), colon (HCT-116) liver (HEPG2) cell lines, as well as normal melanocyte HFB4 was evaluated. Two of these chalcone derivatives with different IC50 and chemical configuration were chosen for molecular studies in detail with MCF-7 cells. Our data indicated that the two compounds prohibit proliferation, angiogenesis, cell cycle progression and induce apoptosis of breast cancer cells. This inhibition is mediated by up regulation of tumor suppressor p53 associated with arrest in S-G2/M of cell cycle. This work provides a confirmation of antitumor activity of the novel chalcones and assists the development of new agents for cancer treatment.

Keywords: Angiogenesis, Apoptosis, Breast carcinoma cell line MCF-7, Caspases, Cell cycle arrest, Chalcones, P53.

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Article Details

VOLUME: 14
ISSUE: 9
Year: 2014
Page: [1282 - 1292]
Pages: 11
DOI: 10.2174/187152061409141010114547
Price: $58