Chalcones Incorporated Pyrazole Ring Inhibit Proliferation, Cell Cycle Progression, Angiogenesis and Induce Apoptosis of MCF7 Cell Line
Magda F. Mohamed,
Mervat S. Mohamed,
Mohamed M. Fathi,
Samia A. Shouman,
Ismail Abdelshafy Abdelhamid.
A Series of chalcone derivatives containing pyrazole ring was prepared and their cytotoxicity against different human cell
lines, including breast (MCF-7), colon (HCT-116) liver (HEPG2) cell lines, as well as normal melanocyte HFB4 was evaluated. Two of
these chalcone derivatives with different IC50 and chemical configuration were chosen for molecular studies in detail with MCF-7 cells.
Our data indicated that the two compounds prohibit proliferation, angiogenesis, cell cycle progression and induce apoptosis of breast
cancer cells. This inhibition is mediated by up regulation of tumor suppressor p53 associated with arrest in S-G2/M of cell cycle. This
work provides a confirmation of antitumor activity of the novel chalcones and assists the development of new agents for cancer
Keywords: Angiogenesis, Apoptosis, Breast carcinoma cell line MCF-7, Caspases, Cell cycle arrest, Chalcones, P53.
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