The Natural Products Journal

Bin Wu
Zhejiang University
Hangzhou
China

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Editorial (Thematic Issue: Emerging Azoles: Structure Function Relationship and Their Therapeutic Potential)

Author(s): Vinod Kumar, Anil K. Sharma.

Abstract:

Natural Products Journal is one of the extremely important journals of Bentham Science Publishers. The current issue has been focused on to uncover many physico-chemical interactions persisting with regards to structural-function relationships of azole compounds and more importantly their therapeutic potential. Efforts have been made to find a link between natural and synthetic azoles’ composition and structure with their physiological or therapeutic role through various articles contributed by diverse range of authors. Here is the brief summary of the articles: Kim et al., emphasized upon Pyrazoline heterocycles which occupy a distinct attention in the field of synthetic and medicinal chemistry exhibiting a wide spectrum of biological activities including anti-inflammatory, anti-microbial, cytotoxic, anticonvulsant etc. [1-3]. Authors have made a sincere effort to review the synthetic and biological significance of Pyrazoline derivatives bringing together most of the recent studies. Varughese et al., shed light on the broad-spectrum antimicrobial and therapeutic role of azole compounds in treating cancer linked fungal infections like candidiasis and aspergillosis. Authors have drawn comparisons between first First generation azoles with that of newer azoles in terms of their action potential and activity against resistant organisms. The role of azoles has been further extended to prostate cancer and breast cancer therapy through this article [4-6]. Sandhu et al., have shown promise in Azoles as effective antifungal agents. Authors are concerned about the growing resistance against azoles in fungal pathogens and side effects accompanied with the use of synthetic azoles which makes it necessary to search for some natural and effective azoles [6-10]. Authors have shown structure-function analysis of clinically important antifungal azoles derivatives through the collection of studies and also reviewed some important patents related to them. Malik et al., mainly gained insight into the mechanistic preview as to how azole compounds bind to lanosterol 14α- demethylase and prevent the demethylation of lanosterol, thereby inhibitiing the fungal growth. Authors have focused their attention on antifungal potential of azole compounds with an emphasis on the corresponding drug resistance episode complemented with novel strategies for the development of new generation of azole compounds [11-14]. Gupta et al., reviewed the antimicrobial importance of natural imidazoles, their mode of actions and structure-activity relationship. The article would certainly help scientific community to bring further modifications or developments in the synthetic methodologies to biologically active compounds based on natural products containing imidazole moiety [15]. Thus natural imidazoles could be used as effective chemotherapeutics in future. Another article by Gupta et al., emphasized upon the effective use of second and third generation azole compounds against systemic fungal infections [16]. Given their toxicity profile being better than that of the first-generation triazoles and drug interactions remain manageable; these compounds represent a true expansion of antifungal arsenal for the future. Kumar and Kaur emphasized upon the use of Triazoles and Oxadiazoles which are nitrogen and nitrogen-oxygen containing heterocycles, for the development of effective chemotherapeutic candidates. The article not only focuses on the biological importance of triazole and oxadiazole derivatives but also highlights synthetic pathways to achieve such compounds which would certainly help the scientific community to bring further developments in the isolation and synthetic methodologies for azole- based novel bioactive agents [17-21]. The continued success of the Journal is the result of a joint effort by a dedicated editorial team under the leadership of Dr. Naeem and we will continue to evolve progressively for the benefit of our contributors and readers. While thanking all the editorial members for their continued support and cohesive interactions, we reiterate our commitment for ethical and quality publications in frontier areas of Natural Product research. The lead guest editors and the executive editor would like to extend their gratitude to authors of this issue for their valuable scientific contributions. We simultaneously thank the valuable comments and suggestions of the reviewers to further improve the quality and scientific perspective of the articles. We eagerly look forward to receiving hot novel areas for contribution to The Natural Products Journal in future. In the end, if you have any questions or suggestions to further improve the journal, please feel free to drop a line to the executive editor of NPJ.

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Article Details

VOLUME: 4
ISSUE: 2
Year: 2014
Page: [71 - 72]
Pages: 2
DOI: 10.2174/221031550402141009094957