Fabrication and Assessment of Gentamicin Loaded Electrospun Nanofibrous Scaffolds as a Quick Wound Healing Dressing Material
Avinash C. Pandey,
Pramod W. Ramteke.
Chronic wounds and ulcers denote a grave ubiquitous complication, and the bacterial contagions
existing in such lesions further impede their successful and swift healing. Wound dressings currently used
are far from being ideal. Consequently, there is a demand to design bio responsive material, which not only sets a mechanical
aid but also cutbacks microbial load and modulates the complex events of tissue regeneration and morphogenesis
by recruiting cells to the wound site. In the current scrutiny, PLGA/Gelatin 70:30 nanofibrous scaffolds laden with gentamicin
were prepared by electrospinning. The compatibility between the constituents of the nanofibrous scaffolds was
determined by Fourier Transform Infrared Spectroscopy, and the physical state of the constituents was studied by Thermogravimetric
analysis. Porosity and swelling index were also calculated and the outcomes revealed a remarkable resemblance
to the extracellular matrix. The in vitro drug release studies manifested a constant drug release deprived of burst effect
designating that the drug was homogeneously dispersed in the scaffold matrix and there was no significant amount of
drug adsorbed onto the surface. This study demonstrated that gentamicin loaded PLGA/Gelatin 70:30 nanofibrous scaffolds
have potential to be used as a promising wound dressing material to prevent bacterial infection at the wound site.
Keywords: Bioresponsive, electrospinning, nanofibrous scaffolds, tissue regeneration, wound dressings.
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