Dietary Polyphenols for Prostate Cancer Therapy
Yan A. Ivanenkov,
Nina V. Chufarova,
Mark S. Veselov,
Alexander G. Majouga.
This review describes the potential of a variety of physiologically active natural dietary polyphenols (PPhs) and
their analogues, including derivatives of flavonoids, stilbenes, lignans, curcuminoids, and tannins, for prostate cancer
chemotherapy. The large number of scientific papers on PPhs published during the last decade, particularly those focused
on their therapeutic potential against prostate cancer cell lines, indicates rising interest in this group of compounds. Several
polyphenolic agents are currently being investigated in advanced clinical trials as prominent cancer drug candidates
while hundreds of related compounds are being evaluated in early clinical and preclinical studies. The review also covers
the key mechanisms of antitumor action of natural PPhs against cancer cells.
Keywords: Chemotherapy, flavonoids, lignans, oncology, polyphenols, prostate cancer, stilbenes, tannins.
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