Current Bioactive Compounds

Adriano Mollica
Department of Pharmacy, University ”G. d' Annunzio” of Chieti-Pescara
Via dei Vestini 31
Chieti, 66100
Italy

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Dietary Polyphenols for Prostate Cancer Therapy

Author(s): Yan A. Ivanenkov, Nina V. Chufarova, Mark S. Veselov, Alexander G. Majouga.

Graphical Abstract:


Abstract:

This review describes the potential of a variety of physiologically active natural dietary polyphenols (PPhs) and their analogues, including derivatives of flavonoids, stilbenes, lignans, curcuminoids, and tannins, for prostate cancer chemotherapy. The large number of scientific papers on PPhs published during the last decade, particularly those focused on their therapeutic potential against prostate cancer cell lines, indicates rising interest in this group of compounds. Several polyphenolic agents are currently being investigated in advanced clinical trials as prominent cancer drug candidates while hundreds of related compounds are being evaluated in early clinical and preclinical studies. The review also covers the key mechanisms of antitumor action of natural PPhs against cancer cells.

Keywords: Chemotherapy, flavonoids, lignans, oncology, polyphenols, prostate cancer, stilbenes, tannins.

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2014
Page: [76 - 111]
Pages: 36
DOI: 10.2174/157340721002141001102524
Price: $58