Current Bioactive Compounds

Adriano Mollica
Department of Pharmacy, University ”G. d' Annunzio” of Chieti-Pescara
Via dei Vestini 31
Chieti, 66100
Italy

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Cholinesterase Inhibition of Selected 4-Methylcoumarins in Comparison to their Antioxidant Activity

Author(s): Sanja C. Zeljkovic, Zbigniew Czarnocki, Anna Zawadzka, Miroslawa Panasiewicz, Franci  Kovac.

Abstract:

Alzheimer’s disease (AD), a progressive neurodegenerative disease has become one of the major health issues in developed countries. Continuing our research on biological activity of coumarin derivatives, this study presents evaluation of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity of series 4- methylcoumarins. All studied compounds showed inhibitory activity in a similar manner as they are capable of scavenging reactive oxygen species and reducing transition metals. This study was focused on structural features that regulate biological activity of 4-methylcoumarins.

Keywords: 4-Methylcoumarins, acetylcholinesterase, antioxidant activity, butyrylcholinesterase.

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2014
Page: [254 - 259]
Pages: 6
DOI: 10.2174/1573407210666141001000556
Price: $58