Resveratrol-Mediated Reversal of Tumor Multi-Drug Resistance

Author(s): Yutong Hu , Chuangang Li , Hong Li , Molin Li , Xiaohong Shu .

Journal Name: Current Drug Metabolism

Volume 15 , Issue 7 , 2014


Abstract:

Multi-drug resistance (MDR) to cancer chemotherapy is a major obstacle to the effective treatment of tumors. Resveratrol, a natural product, may inhibit efflux transporters, such as P-glycoprotein (P-gp), multi-drug resistance-associated protein (MRP) and breast cancer resistance protein (BCRP), and could become a potential multi-drug-resistant regulator. But it remains unclear how resveratrol exerts its reversal effect. In this review, we attempt to reveal the interactions between resveratrol and ABC transporter proteins, and summarize the research profile of resveratrol’s reversal mechanisms, thus to provide pivotal information on the development and application of multi-drug resistance reversal agents.

Keywords: ATP binding cassette transporters, breast cancer resistance protein, multi-drug resistance, multi-drug resistance associated protein, P-glycoprotein, resveratrol.

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Article Details

VOLUME: 15
ISSUE: 7
Year: 2014
Page: [703 - 710]
Pages: 8
DOI: 10.2174/1389200215666140926153522
Price: $58

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