Current Cancer Drug Targets

Ruiwen Zhang 
Texas Tech University Health Sciences Center
1300 Coulter Drive
Amarillo, TX 79106
USA

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The Important Roles of miR-205 in Normal Physiology, Cancers and as a Potential Therapeutic Target

Author(s): Haleh Vosgha, Ali Salajegheh, Robert Anthony Smith, Alfred King-Yin Lam.

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Abstract:

Evidences have demonstrated key mediatory roles of microRNA-205 (miR-205) in normal physiology and its aberrant expression in many cancers. Indeed, miR-205 has been identified as both a tumour suppressive and oncogenic miRNA playing crucial roles in tumourigenesis through regulating different cellular pathways such as cell survival, apoptosis, angiogenesis and metastasis. As a tumour suppressor, miR-205 acts as an inhibitor of cell proliferation, migration and invasion. On the other hand, as an oncogene, miR-205 promotes tumour initiation and development. All these functions act through different target genes in various types of cancers. Also, miR-205 displays potential as a therapeutic target for different cancers. To conclude, miR-205 has important clinical and pathological correlations in different cancers and may act as a diagnostic and prognostic marker as well as new molecular target for cancer therapy.

Keywords: Carcinoma, cancer, miRNA-205, microRNA, oncogene, tumour suppressor gene.

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Article Details

VOLUME: 14
ISSUE: 7
Year: 2014
Page: [621 - 637]
Pages: 17
DOI: 10.2174/156800961407140926105634
Price: $58