Targeting Oncogenes and Tumor Suppressors genes to Mitigate Chemoresistance

Author(s): Tahereh Fatemian, Ezharul Hoque Chowdhury.

Journal Name: Current Cancer Drug Targets

Volume 14 , Issue 7 , 2014

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Abstract:

Malfunctions in membrane transporters or disruptions in signaling cascades induce resistance to chemotherapy in cancer cells resulting in treatment failure. To adjust the genetic alterations leading to these cellular protective measures, dissection and verification of the contributing routes would be required. In justification of knockdown of the key genes, RNA interference provides a reliable probing tool, enabling exploration of phenotypic manifestation of targeted genes. Investigation of the non-transporter targets, predominantly oncogenes and tumor suppressor genes, by means of small interfering RNA with the aim to re-sensitize cancer cells to therapeutics will be discussed in this review.

Keywords: Akt, Bcl-2, cancer, chemoresistance, Her2, MAPK, oncogene, p53, survivin, targeted therapy, tumor suppressor.

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Article Details

VOLUME: 14
ISSUE: 7
Year: 2014
Page: [599 - 609]
Pages: 11
DOI: 10.2174/156800961407140926104458
Price: $58

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