Optimization of the Preparation Condition of 2,4,5-triphenyl-1H-imidazole Over BaSO4 Nanoparticles as Catalyst Using a Response Surface Methodology (RSM)
Mohammad Reza Mohammad Shafiee,
A study on the application of Response Surface Methodology (RSM) for the optimization of the process parameters
of the preparation of 2,4,5-triphenyl-1H-imidazole over BaSO4 nanoparticles as catalyst was explored. A threelevel,
three-factor, Box–Behnken experimental design has been employed to determine the effects of process parameters
namely temperature (20-130 °C), catalyst dosage (0.01-0.5) and initial NH4OAc concentration (2-4 mmol). The second
order mathematical model was developed by regression analysis of the experimental data obtained from 30 runs. Highest
yield of product and lowest time of process were obtained at the optimum conditions as: temperature (130 °C), catalyst
dosage (0.5 mmol) and NH4OAc concentration (4 mmol).
Keywords: 2, 4, 5-triphenyl-1H-imidazole, BaSO4 nanoparticles, Box–Behnken experimental design, response surface methodology.
Rights & PermissionsPrintExport