Contribution of Antimicrobial Peptides to the Development of New and Efficient Antimicrobial Strategies
Mariana Carmen Chifiriuc,
Alexandru Mihai Grumezescu,
Antimicrobial peptides (AMPs) represent promising candidates for the design of novel microbicidal agents, effective
both on planktonic, but especially on antibiotic resistant bacteria, biofilms, and persisters. In addition to their antimicrobial
activity, AMPs also possess other biological activities, such as signalling molecules, immune modulators, drug
delivery vehicles, which could act synergically during the anti-infectious therapy. However, for the clinical development
of peptide-based therapeutics, several challenges including low specificity, susceptibility to proteolytic degradation and
half-lives, potential toxicity to animal cells, need for appropriate carriers are still to be solved. The purpose of this review
is to present synthetic data concerning the structure, mechanisms of action and resistance, as well as the contribution of
nanotechnology and AMPs for the development of new and efficient antimicrobial strategies.
Keywords: Antimicrobial strategies, antimicrobial peptides, microbicidal, membrane pores, nanotechnology, resistance.
Rights & PermissionsPrintExport