Current Proteomics

Bernd Rehm  
Institute of Molecular BioSciences Massey University
Private Bag 11222
Palmerston North
New Zealand

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Contribution of Antimicrobial Peptides to the Development of New and Efficient Antimicrobial Strategies

Author(s): Mariana Carmen Chifiriuc, Alexandru Mihai Grumezescu, Veronica Lazar, Alexandra Bolocan, Stefanos Triaridis, Raluca Grigore, Serban Bertesteanu.

Graphical Abstract:


Abstract:

Antimicrobial peptides (AMPs) represent promising candidates for the design of novel microbicidal agents, effective both on planktonic, but especially on antibiotic resistant bacteria, biofilms, and persisters. In addition to their antimicrobial activity, AMPs also possess other biological activities, such as signalling molecules, immune modulators, drug delivery vehicles, which could act synergically during the anti-infectious therapy. However, for the clinical development of peptide-based therapeutics, several challenges including low specificity, susceptibility to proteolytic degradation and half-lives, potential toxicity to animal cells, need for appropriate carriers are still to be solved. The purpose of this review is to present synthetic data concerning the structure, mechanisms of action and resistance, as well as the contribution of nanotechnology and AMPs for the development of new and efficient antimicrobial strategies.

Keywords: Antimicrobial strategies, antimicrobial peptides, microbicidal, membrane pores, nanotechnology, resistance.

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Article Details

VOLUME: 11
ISSUE: 2
Year: 2014
Page: [98 - 107]
Pages: 10
DOI: 10.2174/157016461102140917121943
Price: $58