Abstract
A series of bisphenol-C derivatives was synthesized by condensing bisphenol-C with benzylchloride, alkylchloroacetates and alkylchloroformates in the presence of anhyd. K2CO3 in THF using catalytic amount of PEG-600. The compounds were characterized by FTIR, 1HNMR, 13CNMR and MS; and assayed for their antibacterial activity against S. aureus MTCC-96, B. subtilis MTCC-441, E. coli MTCC-443, S. typhi MTCC-98 and antifungal activity against A. niger MTCC-282 and A. clavatus MTCC-1323 at different concentrations and compared with standard drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method. 1a-c, 1e-g and 2b-g showed moderate to comparable antibacterial activity against E. coli, S .typhi, B. subtillis and S. aureus. All of these compounds did not show antifungal activity. Increasing hydrophobic chain length, methyl side substituent and aromatic ring affected considerably antibacterial activity.
Keywords: Bisphenols, MIC, microbial assay, PEG-600, SAR.
Letters in Drug Design & Discovery
Title:Synthesis, Characterization and Microbial Activity of New Bisphenol-C Derivatives
Volume: 12 Issue: 2
Author(s): Bhavin Babu Dhaduk, Chirag Bhupendra Patel and Parsotam Hari Parsania
Affiliation:
Keywords: Bisphenols, MIC, microbial assay, PEG-600, SAR.
Abstract: A series of bisphenol-C derivatives was synthesized by condensing bisphenol-C with benzylchloride, alkylchloroacetates and alkylchloroformates in the presence of anhyd. K2CO3 in THF using catalytic amount of PEG-600. The compounds were characterized by FTIR, 1HNMR, 13CNMR and MS; and assayed for their antibacterial activity against S. aureus MTCC-96, B. subtilis MTCC-441, E. coli MTCC-443, S. typhi MTCC-98 and antifungal activity against A. niger MTCC-282 and A. clavatus MTCC-1323 at different concentrations and compared with standard drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method. 1a-c, 1e-g and 2b-g showed moderate to comparable antibacterial activity against E. coli, S .typhi, B. subtillis and S. aureus. All of these compounds did not show antifungal activity. Increasing hydrophobic chain length, methyl side substituent and aromatic ring affected considerably antibacterial activity.
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Cite this article as:
Dhaduk Babu Bhavin, Patel Bhupendra Chirag and Parsania Hari Parsotam, Synthesis, Characterization and Microbial Activity of New Bisphenol-C Derivatives, Letters in Drug Design & Discovery 2015; 12 (2) . https://dx.doi.org/10.2174/1570180811666140915222545
DOI https://dx.doi.org/10.2174/1570180811666140915222545 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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