Synthesis, Characterization and Microbial Activity of New Bisphenol-C Derivatives

Title:Synthesis, Characterization and Microbial Activity of New Bisphenol-C Derivatives

Volume: 12 Issue: 2

Author(s): Bhavin Babu Dhaduk, Chirag Bhupendra Patel and Parsotam Hari Parsania

Affiliation:

Keywords: Bisphenols, MIC, microbial assay, PEG-600, SAR.

Abstract: A series of bisphenol-C derivatives was synthesized by condensing bisphenol-C with benzylchloride, alkylchloroacetates and alkylchloroformates in the presence of anhyd. K₂CO₃ in THF using catalytic amount of PEG-600. The compounds were characterized by FTIR, ¹HNMR, ¹³CNMR and MS; and assayed for their antibacterial activity against S. aureus MTCC-96, B. subtilis MTCC-441, E. coli MTCC-443, S. typhi MTCC-98 and antifungal activity against A. niger MTCC-282 and A. clavatus MTCC-1323 at different concentrations and compared with standard drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method. 1a-c, 1e-g and 2b-g showed moderate to comparable antibacterial activity against E. coli, S .typhi, B. subtillis and S. aureus. All of these compounds did not show antifungal activity. Increasing hydrophobic chain length, methyl side substituent and aromatic ring affected considerably antibacterial activity.

Cite this article as:

Dhaduk Babu Bhavin, Patel Bhupendra Chirag and Parsania Hari Parsotam, Synthesis, Characterization and Microbial Activity of New Bisphenol-C Derivatives, Letters in Drug Design & Discovery 2015; 12 (2) . https://dx.doi.org/10.2174/1570180811666140915222545