Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis, Characterization and Microbial Activity of New Bisphenol-C Derivatives

Author(s): Bhavin Babu Dhaduk, Chirag Bhupendra Patel, Parsotam Hari Parsania.

Graphical Abstract:


Abstract:

A series of bisphenol-C derivatives was synthesized by condensing bisphenol-C with benzylchloride, alkylchloroacetates and alkylchloroformates in the presence of anhyd. K2CO3 in THF using catalytic amount of PEG-600. The compounds were characterized by FTIR, 1HNMR, 13CNMR and MS; and assayed for their antibacterial activity against S. aureus MTCC-96, B. subtilis MTCC-441, E. coli MTCC-443, S. typhi MTCC-98 and antifungal activity against A. niger MTCC-282 and A. clavatus MTCC-1323 at different concentrations and compared with standard drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro broth dilution method. 1a-c, 1e-g and 2b-g showed moderate to comparable antibacterial activity against E. coli, S .typhi, B. subtillis and S. aureus. All of these compounds did not show antifungal activity. Increasing hydrophobic chain length, methyl side substituent and aromatic ring affected considerably antibacterial activity.

Keywords: Bisphenols, MIC, microbial assay, PEG-600, SAR.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2015
Page: [152 - 157]
Pages: 6
DOI: 10.2174/1570180811666140915222545
Price: $58