Targeting SUMOylation Cascade for Diabetes Management

Author(s): Dornadula Sireesh, Elango Bhakkiyalakshmi, Kunka Mohanrama Ramkumar, Shanmugakani Rathinakumar, Panneer Selvam Anto Jennifer, Palanisamy Rajaguru, Ramasamy Paulmurugan.

Journal Name: Current Drug Targets

Volume 15 , Issue 12 , 2014

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Abstract:

Post-translational modifications (PTMs) play important roles in regulating protein stability, trafficking, folding conformation, and functional activity. Small ubiquitin-like modifier (SUMO) protein mediates a distinct type of PTM called SUMOylation in which the SUMO protein is covalently ligated to the target protein and modifies its activities through a series of enzymatically-catalyzed reactions. SUMOylation regulates many cellular processes like transcription, the maintenance of the ion gradient across the cell membrane, stress response, autoimmunity, etc. Several target proteins of SUMOylation are involved in the biological pathways related to various human diseases, including cardiovascular diseases, diabetes, cancer, and neurodegenerative disorders. This review focuses on the SUMOylation process, regulatory roles of SUMOylation in diabetes, and prospects of developing novel anti-diabetic drugs targeting the SUMOylation process.

Keywords: Diabetes, post-translational modification, SUMO inhibitors, SUMO targets, SUMOylation.

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Article Details

VOLUME: 15
ISSUE: 12
Year: 2014
Page: [1094 - 1106]
Pages: 13
DOI: 10.2174/1389450115666140915124747
Price: $58

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