Nanoparticle-based Diagnostic Imaging of Inflammation in Rheumatic Disease
Jennifer L. Rogers,
Jason S. Kim.
A variety of imaging modalities assists in the diagnosis and assessment of rheumatoid arthritis and of other
rheumatic disorders; however, the definitive diagnosis of inflammatory arthritides can be challenging, especially in the
early stages of disease. Consequently, there is significant research underway in expanding imaging sensitivity and
specificity to aid in diagnostics of early stage inflammation and management of subclinical disease activity. Nanotechnology,
the manipulation of materials in the nanoscale range (1 to 1000nm), is increasingly utilized in the biomedical
field to meet this need, particularly as novel contrast agents in imaging. In this review, the use of superparamagnetic
iron oxide (SPIO), gold, and chitosan glyco-nanoparticles will be discussed in their imaging capabilities pertaining to
rheumatic diseases as well as emerging multimodal nanomaterials that could have future biomedical applications in the
imaging of inflammation.
Keywords: Imaging, nanoparticles, rheumatoid arthritis, USPIO.
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