Background: Adolescents who have autistic features, such as social communication deficits, as well as disorganized
thinking and bizarre behavior, present diagnostic challenges for clinicians as well as for researchers. Autism and
schizophrenia are both neurodevelopmental disorders; they have an interconnected history that has diverged diagnostically,
but retains many shared characteristics. Once conceptualized as a type of schizophrenia, autism has separated into a
distinct disorder, yet similarities are evident between the two. Recent research has called into question the complete dichotomous
separation of these two disorders.
Methods: This review covers the history, as well as the shared phenotypic and genotypic characteristics of the disorders,
including genetics, imaging, language development, and social functioning. We present possible theoretical constructs to
frame the nature and extent of the overlap given the available research.
Results: Adolescents who have childhood histories consistent with autistic spectrum disorders can present with psychotic
symptoms in adolescence. Conversely, adolescents who appear to have childhood or adolescent onset schizophrenia may
also show autistic features. Various hypotheses have been proposed to explain the overlap between these two heterogeneous
Conclusions: We believe that the overlaps between autism and schizophrenia represent an important and rich area of research
in order to better understand the unique characteristics of each disorder that may help to aid understand mechanisms
of development, refine models of prediction and risk, as well as to understand common characteristics that may help
shape entry points for future intervention.