Abstract
Stroke is one of the most common cardiovascular diseases and is known as a leading cause of death in the world. Despite to its high prevalence, there are limited effective therapeutic strategies for stroke till now. However, oxidative stress plays an important role in the pathogenesis of stroke and therefore, antioxidant therapy could be used as a new therapeutic strategy. Among the antioxidants, some natural compounds are very interesting due to their low adverse effects. Resveratrol (3, 5, 4’-trihydroxystilbene) is a natural polyphenolic antioxidant found in grape skin, grape products, and peanuts as well as in red wine. In recent years, much attention has been paid to resveratrol due to its wide range of antioxidant actions. Resveratrol possesses cardioprotective actions through stimulation of nitric oxide production as well as antioxidative and anti-inflammatory effects. Here we review the available literatures on beneficial role of resveratrol on ischemic stroke. We also provide information about chemistry, sources, bioavailability, as well as clinical impacts of resveratrol.
Keywords: Antioxidants, neuroprotection, oxidative stress, polyphenol, resveratrol, stroke.
Current Neurovascular Research
Title:Resveratrol and Stroke: from Chemistry to Medicine
Volume: 11 Issue: 4
Author(s): Seyed Fazel Nabavi, Huige Li, Maria Daglia and Seyed Mohammad Nabavi
Affiliation:
Keywords: Antioxidants, neuroprotection, oxidative stress, polyphenol, resveratrol, stroke.
Abstract: Stroke is one of the most common cardiovascular diseases and is known as a leading cause of death in the world. Despite to its high prevalence, there are limited effective therapeutic strategies for stroke till now. However, oxidative stress plays an important role in the pathogenesis of stroke and therefore, antioxidant therapy could be used as a new therapeutic strategy. Among the antioxidants, some natural compounds are very interesting due to their low adverse effects. Resveratrol (3, 5, 4’-trihydroxystilbene) is a natural polyphenolic antioxidant found in grape skin, grape products, and peanuts as well as in red wine. In recent years, much attention has been paid to resveratrol due to its wide range of antioxidant actions. Resveratrol possesses cardioprotective actions through stimulation of nitric oxide production as well as antioxidative and anti-inflammatory effects. Here we review the available literatures on beneficial role of resveratrol on ischemic stroke. We also provide information about chemistry, sources, bioavailability, as well as clinical impacts of resveratrol.
Export Options
About this article
Cite this article as:
Nabavi Fazel Seyed, Li Huige, Daglia Maria and Nabavi Mohammad Seyed, Resveratrol and Stroke: from Chemistry to Medicine, Current Neurovascular Research 2014; 11 (4) . https://dx.doi.org/10.2174/1567202611666140912114833
DOI https://dx.doi.org/10.2174/1567202611666140912114833 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Antiplatelet Therapy in TAVI: Current Clinical Practice and Recommendations
Current Pharmaceutical Design Interactions Between Plasma Proteins and Naturally Occurring Polyphenols
Current Drug Metabolism Traditional and Alternative Therapies for Refractory Angina
Current Pharmaceutical Design New Oral Anticoagulants in Coronary Artery Disease
Cardiovascular & Hematological Disorders-Drug Targets Targeting Cyclooxygenase and Nitric Oxide Pathway Cross-Talk: A New Signal Transduction Pathway for Developing More Effective Anti- Inflammatory Drugs
Current Signal Transduction Therapy Lifestyle Changes and Surgical Treatment for Hypertension in the Elderly
Cardiovascular & Hematological Agents in Medicinal Chemistry Should Percutaneous Coronary Intervention be the Standard Treatment Strategy for Significant Coronary Artery Disease in all Octogenarians?
Current Cardiology Reviews PGD and Prenatal Diagnosis: Comparison and Review in Different Genetic Disorders
Current Women`s Health Reviews Revascularization vs. Optimal Medical Therapy in Women with NSTE-ACS
Current Pharmaceutical Design Pathophysiology of Atherosclerotic Plaque Development
Cardiovascular & Hematological Agents in Medicinal Chemistry Targeted Intraoperative Radiotherapy Tumour Bed Boost During Breast Conserving Surgery after Neoadjuvant Chemotherapy in HER2 Positive and Triple Negative Breast Cancer
Reviews on Recent Clinical Trials Cigarette Smoke-Induced Proteostasis Imbalance in Obstructive Lung Diseases
Current Molecular Medicine Lipid-Lowering Drugs Acting at the Level of the Gastrointestinal Tract
Current Pharmaceutical Design Evaluation of Salivary Lipid Peroxidation End Product Level in Dental Caries
Infectious Disorders - Drug Targets Diagnosis of Cardiovascular Diseases Using Retinal Images Through Vessel Segmentation Graph
Current Medical Imaging Early Vascular Aging: A New Target for Hypertension Treatment
Current Pharmaceutical Design Cardiac Remodeling and Exercise Training in Hypertension
Current Hypertension Reviews Interventions to Prevent Long-Term Consequences of Bronchiolitis
Current Respiratory Medicine Reviews Manipulation and Engineering of Metabolic and Biosynthetic Pathway of Plant Polyphenols
Current Pharmaceutical Design Wharton's Jelly Mesenchymal Stem Cell Response on Chitosan-graft-poly (ε-caprolactone) Copolymer for Myocardium Tissue Engineering
Current Pharmaceutical Design