Abstract
Three series of novel bile acid conjugates with different –amino acid have been synthesized. The synthesis of final compounds was accomplished with anhydride using ethyl chloroformate. The conjugation was introduced via coupling of the bile acid anhydride with appropriately functionalized α-amino acid. Biological evaluation of synthesized compounds was carried out in vitro for their antimicrobial and antifungal properties against human pathogens. The bile acid conjugates 1g, 2g, 2h and 3g indicated 2–fold stronger antimicrobial activity compared to ciprofloxacin. The final products were obtained in both high yield and purity. The prepared conjugated bile acids were characterized by mass spectrometry, infrared spectroscopy and nuclear magnetic resonance proton spectroscopy which are also discussed along with the thin–layer chromatographic properties.
Keywords: α-amino acids, antimicrobial activity, bile acids, conjugated bile acid, MIC values.
Current Bioactive Compounds
Title:Antibacterial and Antifungal Screening of Novel α-amino Acid Conjugated Bile Acid Derivatives
Volume: 10 Issue: 4
Author(s): Kalpesh Parikh, Dhaval Savaliya and Deepkumar Joshi
Affiliation:
Keywords: α-amino acids, antimicrobial activity, bile acids, conjugated bile acid, MIC values.
Abstract: Three series of novel bile acid conjugates with different –amino acid have been synthesized. The synthesis of final compounds was accomplished with anhydride using ethyl chloroformate. The conjugation was introduced via coupling of the bile acid anhydride with appropriately functionalized α-amino acid. Biological evaluation of synthesized compounds was carried out in vitro for their antimicrobial and antifungal properties against human pathogens. The bile acid conjugates 1g, 2g, 2h and 3g indicated 2–fold stronger antimicrobial activity compared to ciprofloxacin. The final products were obtained in both high yield and purity. The prepared conjugated bile acids were characterized by mass spectrometry, infrared spectroscopy and nuclear magnetic resonance proton spectroscopy which are also discussed along with the thin–layer chromatographic properties.
Export Options
About this article
Cite this article as:
Parikh Kalpesh, Savaliya Dhaval and Joshi Deepkumar, Antibacterial and Antifungal Screening of Novel α-amino Acid Conjugated Bile Acid Derivatives, Current Bioactive Compounds 2014; 10 (4) . https://dx.doi.org/10.2174/1573407210666140909201409
DOI https://dx.doi.org/10.2174/1573407210666140909201409 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Capillary Electrophoresis with Mass Spectrometry: Applications to Metabolomic Analysis
Current Metabolomics Somatostatin and its Analogs
Current Drug Targets Chemoprevention with Phytonutrients and Microalgae Products in Chronic Inflammation and Colon Cancer
Current Pharmaceutical Design Delivery of Peptidic Gonadotropin Releasing Hormone Antagonists
Current Drug Delivery Inflammatory Bowel Disease and Celiac Disease: Overlaps in the Pathology and Genetics, and their Potential Drug Targets
Endocrine, Metabolic & Immune Disorders - Drug Targets Gold Nanoparticle Based Systems in Genetics
Current Pharmacogenomics Neuroglobin and Estrogen Receptors: A New Pathway of Cell Survival and Cell Death Balance
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Functionalization of Phenols Using a Biomimetic Couple of Sodium Nitrite/Hydrogen Peroxide in an Acidic Medium
Current Organic Chemistry MALT Lymphoma, Stress Ulcer and Cholinergic Nerves from the Viewpoint of Bilateral and Unilateral Truncal Vagotomy and Substance P
Current Pharmaceutical Design Retinol-Binding Protein 4 and New Adipocytokines in Nonalcoholic Fatty Liver Disease
Current Pharmaceutical Design Biological Relevance of DNA Polymerase Beta and Translesion Synthesis Polymerases to Cancer and its Treatment
Current Molecular Pharmacology Recent Development of Chitosan Nanocomposites for Environmental Applications
Recent Patents on Nanotechnology Relevance of Drug Metabolizing Enzyme Activity Modulation by Tea Polyphenols in the Inhibition of Esophageal Tumorigenesis
Medicinal Chemistry Is Red Meat Required for the Prevention of Iron Deficiency Among Children and Adolescents?
Current Pediatric Reviews A Review on Antiproliferative and Apoptotic Activities of Natural Honey
Anti-Cancer Agents in Medicinal Chemistry Approaches for Imaging the Diabetic Pancreas: First Results
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Reversal of Resistance to Oxazaphosphorines
Current Cancer Drug Targets DNA Intercalators in Cancer Therapy: Organic and Inorganic Drugs and Their Spectroscopic Tools of Analysis
Mini-Reviews in Medicinal Chemistry Pharmacognostical Overview of “Gunma Kuligai” – a Traditional Siddha Preparation for Treating Acid Peptic Disease (APD)
Current Traditional Medicine Molecular and Clinical Analysis of Predictive Biomarkers in Non-Small-Cell Lung Cancer
Current Medicinal Chemistry