Alzheimer's disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral
cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD
and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group.
However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial
effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of
AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants,
estrogens and immunotherapeutics.
Keywords: Amyloid aggregation inhibitors, antioxidants, beta-sheet breakers, estrogens, immunotherapeutic Abeta, neurodegeneration.
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