Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Non-Classical Therapeutic Approach in the Treatment of Alzheimer's Disease: A Mini Review

Author(s): Vladan Bajic, Biljana Spremo-Potparevic, Lada Zivkovic, Emina Sudar, Sonja Zafirovic, Milan Obradovic, Esma R. Isenovic.

Graphical Abstract:


Abstract:

Alzheimer's disease (AD) is a multi factorial disease, related to the loss of neurons and synapses in cerebral cortex and subcortical structures, leading to degenerative changes and atrophy. Despite abundance of facts related to AD and its pathology, the only drugs used in the prevention and treatment are those from the cholinesterase inhibitors group. However, there is growing evidence that a non-classical therapeutic approach in the treatment of AD has beneficial effects. In this review we summarized recent literature data related to the non-classical drugs for the treatment of AD predominantly used in clinical testing, such as amyloid aggregation inhibitors, beta-sheet breakers, antioxidants, estrogens and immunotherapeutics.

Keywords: Amyloid aggregation inhibitors, antioxidants, beta-sheet breakers, estrogens, immunotherapeutic Abeta, neurodegeneration.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2015
Page: [158 - 164]
Pages: 7
DOI: 10.2174/1570180811666140909010803
Price: $58