The aligned manuscript reports synthesis, screening and QSAR analysis of twenty six 1, 2, 4-triazole analogues from their respective
aromatic carboxylic acids. The structures of synthesized analogues were characterized using physical and spectral analysis. 1, 2,
4-Triazole analogs antioxidant capacity was determined using DPPH radical scavenging assay. Results revealed that out of L, T & VRT
series, VRT series of 1, 2, 4-triazoles have significant antioxidant activities when compared with standard ascorbic acid. To obtain structural
insights for development of new antioxidants a 2D-QSAR analysis of this dataset of 26 molecules was performed. The 2D-QSAR
models correlate with the in vitro results and explain the salient structural features predominant in the molecules responsible for antioxidant
Keywords: 1, 2, 4-Triazoles, Antioxidant activity, DPPH radical assay, 2D-QSAR.
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