Editorial (Thematic Issue: Current Topics in Pharmacogenomics)

Author(s): Siva Kumar Panguluri, Kevin B. Sneed, Yashwant Pathak, Shufeng Zhou.

Journal Name: Recent Patents on Biotechnology

Volume 8 , Issue 2 , 2014

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The special issue “Current topics in Pharmacogenomics”, will be wonderful reference for new generation pharmacists & future pharmacists to understand the current status of Pharmacogenomics (Future medicine or personalized medicine) and its future prospects. “No two individuals are alike” and diversities among the individuals can potentially contribute their reaction (positive or negative) to the drug. The main focus of Human Genome Project is developing personalized medicine based on the genome content of the individual to maximize the drug efficacy and minimize the un-wanted side effects. Disciplines such as Biotechnology, Bioinformatics, Genomics, Genetic Engineering, Molecular Biology, Pharmaceuticals Sciences, Clinical Practice, and Mathematics are the core of Pharmacogenomics. The main focus of this issue is to bring novel research topics, development of new pharmacogenomics tools in personalized medicine for major diseases and few patents in these areas. From a therapeutic approach, the future of pharmacy and pharmacogenomics will be a major guiding tool for drug therapy which will move the clinical practice away from “one size fits all” approach. Few topics have also been included to cover the research developing novel diagnostics, biomarkers and preventive solutions using one or more of the core areas of Pharmacogenomics. The first review article in this special issue contributed by Dr. Andrew Borkowski et al. discusses on the implications of polymorphisms in warfarin dosing, pharmacogenomics tests available for warfarin dosing along with the clinical model for the implementation of pharmacogenomics test results and complexities associated with these patented methodologies. Second review contributed by Dr. John Allen et al. discusses the potential use of pharmacogenomic approaches in the critically ill for the management of acute coronary syndrome (ACS), invasive fungal infection, and pain management along with some recent patents associated with it and the current barriers for Pharmacogenomics-guided therapy in the critically ill. Third review contributed by Dr. Kalyan Chapalamadugu et al. discusses various pharmacogenomics approaches for cardiovascular complications in patients with metabolic disorders such as diabetes and obesity. Fourth review contributed by Dr. Ashim Malhotra et al. highlights for the first time on the possible sources of pharmacogenomics variations that may affect the treatment of the pediatric cardiomyopathy called Barth syndrome (BTHS). In this article authors also shed light on the possible treatment options along with the future directions. Fifth article contributed by Dr. Charles Preuss et al. elucidates upon the potential role of nutraceuticals (natural products) as dietary supplements to prevent or diminish the disease risk in the population carrying certain polymorphisms that can increase the susceptibility to certain diseases. Sixth article contributed by Dr. Thea Moore et al. focuses on the current impression of pharmacogenomics in reducing the life-threatening adverse effects of psychotropics in patients with psychiatric and neurological disorders with special emphasis on atypical antipsychotics due to their wide usage. Finally, the seventh article contributed by Dr. Manju Pathak discusses the role of functional foods in disease management for patients with Type 2 Diabetes Mellitus. We are grateful to all contributors of this special issue and to all our reviewers for their excellent feedback, which made this issue a wonderful guide for the future pharmacists and pharmacogenomics specialists. I wish this special issue will give more encouragement for the scientific community to bring more special issues, topics and books that can promote complete implementation of pharmacogenomics in clinical settings.

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Article Details

Year: 2014
Page: [109 - 109]
Pages: 1
DOI: 10.2174/1872208309666140904124649

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PDF: 31