The industrial production of recombinant proteins preferentially requires the generation of stable cell lines expressing
proteins in a quick, relatively facile, and a reproducible manner. Different methods are used to insert exogenous
DNA into the host cell, and choosing the appropriate producing cell is of paramount importance for the efficient production
and quality of the recombinant protein. This review addresses the advances in recombinant protein production in
mammalian cell lines, according to key patents from the last 30 years.
Keywords: Mammalian expression system, patents in biopharmaceuticals, recombinant protein.
Rights & PermissionsPrintExport