Warfarin Pharmacogenomics: Recommendations With Available Patented Clinical Technologies

Author(s): Andrew A. Borkowski, Avni Kardani, Stephen M. Mastorides, L. Brannon Thomas.

Journal Name: Recent Patents on Biotechnology

Volume 8 , Issue 2 , 2014

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Warfarin pharmacogenomic testing has become a prime example of the utility of personalized molecular testing in the modern clinical laboratory. Warfarin is a commonly used drug for the prevention and treatment of thromboembolic complications in a variety of clinical situations. However, a number of factors lead to a high interindividual variability in dose requirements. Among the primary factors in this variability are genetic polymorphisms in general patient populations, which can account for 35-50% of varying dose requirements among patients. In this review, we discuss the implications of polymorphisms in the cytochrome P-450 enzyme 2C9 (CYP2C9) and Vitamin K Epoxide Reductase Enzyme Complex subunit 1 (VKORC1) as they relate to therapeutic warfarin dosing. We discuss the clinical utility of pharmacogenomics testing as related to warfarin dosing, and propose a clinical model for the implementation of the pharmacogenomic test results. Finally, we provide a brief overview of the currently available commercial testing platforms with discussion of the complexities of utilizing patented methodologies in bringing genetic testing such as this to the clinical laboratory.

Keywords: Biotechnology, patents, pharmacogenomics, pharmacogenetics, warfarin.

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Article Details

Year: 2014
Page: [110 - 115]
Pages: 6
DOI: 10.2174/1872208309666140904112003

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PDF: 55