We studied cerebrospinal fluid (CSF) flow dynamics at the cervical level in association with internal jugular
vein (IJV) flow for 92 patients with multiple sclerosis (MS). Phase contrast magnetic resonance imaging was used to
quantify flow of the CSF and major vessels (including the IJV and the carotid arteries) at the C2-C3 level in the neck.
Contrast enhanced MR angiography and time-of-flight MR venography were used to subdivide MS patients into stenotic
(ST) and non-stenotic (NST) populations. We evaluated: IJV flow normalized by arterial flow; CSF peaks; CSF outflow
duration and its onset from systole. We tested if these variables were statistically different among different MS
phenotypes and between ST and NST MS patients. The delay between the beginning of systole and the CSF outflow was
higher in ST compared to NST MS. Less IJV flow was observed in ST vs NST MS. None of the measures was different
between the different MS phenotypes. These results suggest that alterations of IJV morphology affect both IJV flow and
CSF flow timing but not CSF flow amplitude.
Keywords: Cerebrospinal fluid, multiple sclerosis, phase contrast mri, venous stenosis.
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