The robust of fluorescent techniques to study the ligand-receptor interaction followed by rapidly developing
fluorescence imaging techniques resulted in a burst of the novel fluorescent ligands development. Taking into consideration
not only ligand’s high affinity to the receptor, but also their fluorescent properties to visualize the interaction even in
the single cell level, gives the researchers a strong impulse to investigate that field of GPCR ligands. Moreover, paying attention
to the “non pharmacological” advantages of these ligands, as well as the techniques to be used, fluorescent ligands
become commonly used pharmacological tools to study GPCRs. Herein we report on the results described in the literature
since late 2007 in the field of the fluorescent GPCR small, non-peptide ligands according the receptor affinity, fluorophores
that has been used to tag the molecules and their fluorescent properties as well as their application in GPCR research.
Keywords: Dimerization, fluorescence, fluorescent ligands, fluorophores, GPCRs, oligomerization.
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