The search for cheap, easy-to-use and effective spermicides and microbicides to help avoid unwanted pregnancies
and the transmission of sexually transmitted diseases has been ongoing for many years. This review takes into account
compounds designed to act both as microbicides and spermicides for multipurpose prevention, and focuses on the
required methodological studies to evaluate their safety, especially cytotoxicity. A comprehensive literature review was
conducted on the synthesis, development, advantages and disadvantages of vaginal multi-function compounds. The available
data shows that after several setbacks, there is a current interest in the synthesis and in the activity of novel dualfunction
substances.. The study of well-known compounds with distinctive mechanisms of action provides a solid starting
point to explore the possible development of such strategies. However, a completely safe and efficient compound for
commercialization has yet to be identified.
Keywords: Contraception, microbicides, multipurpose prevention compounds, sexually transmitted diseases, sperm, spermicides.
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