A series of novel substituted quinazolin-4(3H)-one derivatives were synthesized and screened in vivo for their
antihypertensive activities. Out of eighteen synthesized compounds, seven i.e. 2a, 2c, 4a, 4d, 5d, 6a & 6b compounds
have shown hypotensive effect and produced bradycardia. These compounds have shown better activity than reference
drug Prazosin (which acts as anti-hypertensive agent by α1 blocking action). All the compounds have shown
ALD50>1000mg/kg with maximum in 2c & 4d (>1200mg/kg).
Keywords: Antihypertensive, alpha adrenoceptors, bradycardia, ALD50, N, N’ dimethyl amine, NE response, piperazine,
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