Lone Atrial Fibrillation: Electrophysiology, Risk Factors, Catheter Ablation and Other Non-pharmacologic Treatments

Author(s): Arun Kanmanthareddy, Martin P. Emert, Rhea C. Pimentel, Yeruva Madhu Reddy, Sudharani Bommana, Donita Atkins, Rachana Tadakamalla, Thanmay Lakkireddy, Dhanunjaya Lakkireddy.

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 5 , 2015

Abstract:

Atrial fibrillation occurring in the absence of cardiovascular disease in individuals younger than 60 years is known as lone atrial fibrillation. Nearly 1-12% of atrial fibrillation is considered to be lone atrial fibrillation. As our understanding of atrial fibrillation grows, we wonder as to whether there is such as thing as “lone” atrial fibrillation? We know that male sex, obesity, obstructive sleep apnea, alcohol consumption and endurance sports increase the risk of developing lone atrial fibrillation. Family history of atrial fibrillation increases the risk strongly and there are several recognized mutations that are causative of lone atrial fibrillation. Common triggers for origin of atrial fibrillation are the pulmonary veins. The atrial substrate provides the reentry circuits for perpetuating the arrhythmia. The autonomic nervous system is a key modulator and allows the continuation of the atrial fibrillation. Catheter ablation has been very effective in the treatment of this condition. The ablation procedure involves isolation of the pulmonary veins, antrum, complex fractionated electrograms and other sites. Alternatively surgical techniques can be used to isolate the pulmonary veins and surgical techniques have evolved to minimally invasive procedures and these are as effective as catheter ablation. Early intervention improves the left atrial remodeling and may lead to fewer recurrences.

Keywords: Lone atrial fibrillation, electrophysiology of lone atrial fibrillation, catheter ablation of lone atrial fibrillation, Nonpharmacological treatments of lone atrial fibrillation.

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Article Details

VOLUME: 21
ISSUE: 5
Year: 2015
Page: [580 - 590]
Pages: 11
DOI: 10.2174/1381612820666140825130524
Price: $58

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