Polyphenols in Disease: from Diet to Supplements
Ramon Rodrigo, Matias Libuy, Felipe Feliu and Daniel Hasson
Affiliation: Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Casilla 70058, Santiago 7, Chile.
Keywords: Antioxidants, chronic non-communicable diseases, oxidative stress, polyphenols, resveratrol.
Polyphenols are a structural class of natural and synthetic, organic chemicals characterized mainly by the presence
of phenol structural units. Numerous epidemiological and experimental studies have strongly suggested their beneficial
effects for human health. This view is supported by their biological activities, which are associated with chemical and
biochemical properties, including the ability to act as antioxidants, their antineoplastic effect and the regulation of gene
expression in chronic degenerative diseases. These mechanisms of action could account for their preventive and therapeutic
uses in human subjects. Moreover, in some therapeutic uses, such as antineoplastic effect, a prooxidant therapeutic action
has been suggested. In the diet, numerous compounds could participate in the beneficial properties, and this likely
could result in synergistic effects because the whole effect is better than the separately action of each compound. However,
the pharmacokinetic and pharmacodynamic properties of these bioactive micronutrients are yet to be further characterized.
More research is required to fully establish the therapeutic use of polyphenols against human disease. Based on
biological and pharmacological properties of polyphenols both as diet components and supplements, the objective of this
work is to show an updated version about the role that polyphenols could play in several chronic diseases such as hypertension,
diabetes mellitus, cancer and neurodegenerative disorders.
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