Cofactor Biosynthetic Pathways in Mycobacterium tuberculosis as Potential Drug Targets
There are many chemotherapeutic interventions available for tuberculosis (TB) and are in use for more than
five decades, but still there is an urgent need for novel drugs against new targets due to emergence of resistant strains.
Moreover, the ability of Mycobacterium tuberculosis (Mtb) to survive within granulomas in a non-replicating latent stage
prolongs the course of drug dose and hence increases the severity of the disease. The significant rerouting of metabolism
is one of the key processes that help mycobacteria adapt to the hostile environment of host granuloma. In this review, we
are focusing on some of the cofactor biosynthetic pathways of Mycobacterium tuberculosis and their utilization as drug
Keywords: FAD, Mtb, NAD, Pantothenate, iron, vitamin.
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