Accelerated Labeling Methods and Syntheses of Radiotracers Utilizing Microfluidic Technology
Katherine Hargrove and Graham B. Jones
Affiliation: Bioorganic and Medicinal Chemistry Laboratories, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115, USA.
Keywords: Flow chemistry, green chemistry, labeling, Microfluidics, PET, radiopharmaceuticals, synthesis.
Positron emission tomography [PET] is a powerful nuclear clinical imaging technique used for the detection
and treatment of central nervous system (CNS) disorders, cardiovascular diseases, and certain cancers. Due to the often
short half-lives of the radiolabeled compounds employed, the availability of relevant tracers is severely limited. Through
the use of microfluidic techniques many of the limitations of conventional synthesis of radiotracers are alleviated, paving
the way for diverse families of compounds to be developed with defined targets for imaging. This review will survey syntheses
of various radiotracers using new microfluidic techniques being developed.
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