Abstract
Stem cells, which maintain self-renewal behavior and produce multiple mature cells, are recognized to be the best cell source for transplantation in regenerative medicine. Recently, stem-cell based transplantation has become an important pre-clinical attempt for neuronal injury and degeneration diseases, such as spinal cord injury, amyotrophic lateral sclerosis, and Alzheimer disease. However, the poor survival rate of stem cells and only a limited number of induced neurons from the cells were found in pre-clinical trials. Therefore, it is necessary to develop a rational procedure for stem cells transplantation. This review summarizes recent promising progress in the investigation of stem cell and biomaterials, and hypothesizes a useful transplant approach for stem cell therapy in neuronal diseases.
Keywords: Neuronal regenerative, stem cell therapy, transplantation therapy.
Current Signal Transduction Therapy
Title:A Hypothesis for Regenerative Therapy for Neuronal Disease: Stem Cells within Artificial Niche
Volume: 9 Issue: 1
Author(s): Jialin Liu, Zhiwen Zhang, Jinghui Xue, Haitao Zhang, Yuxiao Liu and Fengyun Hu
Affiliation:
Keywords: Neuronal regenerative, stem cell therapy, transplantation therapy.
Abstract: Stem cells, which maintain self-renewal behavior and produce multiple mature cells, are recognized to be the best cell source for transplantation in regenerative medicine. Recently, stem-cell based transplantation has become an important pre-clinical attempt for neuronal injury and degeneration diseases, such as spinal cord injury, amyotrophic lateral sclerosis, and Alzheimer disease. However, the poor survival rate of stem cells and only a limited number of induced neurons from the cells were found in pre-clinical trials. Therefore, it is necessary to develop a rational procedure for stem cells transplantation. This review summarizes recent promising progress in the investigation of stem cell and biomaterials, and hypothesizes a useful transplant approach for stem cell therapy in neuronal diseases.
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Cite this article as:
Liu Jialin, Zhang Zhiwen, Xue Jinghui, Zhang Haitao, Liu Yuxiao and Hu Fengyun, A Hypothesis for Regenerative Therapy for Neuronal Disease: Stem Cells within Artificial Niche, Current Signal Transduction Therapy 2014; 9 (1) . https://dx.doi.org/10.2174/1574362409666140820225940
DOI https://dx.doi.org/10.2174/1574362409666140820225940 |
Print ISSN 1574-3624 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-389X |
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