A Hypothesis for Regenerative Therapy for Neuronal Disease: Stem Cells within Artificial Niche

Author(s): Jialin Liu, Zhiwen Zhang, Jinghui Xue, Haitao Zhang, Yuxiao Liu, Fengyun Hu.

Journal Name: Current Signal Transduction Therapy

Volume 9 , Issue 1 , 2014

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Abstract:

Stem cells, which maintain self-renewal behavior and produce multiple mature cells, are recognized to be the best cell source for transplantation in regenerative medicine. Recently, stem-cell based transplantation has become an important pre-clinical attempt for neuronal injury and degeneration diseases, such as spinal cord injury, amyotrophic lateral sclerosis, and Alzheimer disease. However, the poor survival rate of stem cells and only a limited number of induced neurons from the cells were found in pre-clinical trials. Therefore, it is necessary to develop a rational procedure for stem cells transplantation. This review summarizes recent promising progress in the investigation of stem cell and biomaterials, and hypothesizes a useful transplant approach for stem cell therapy in neuronal diseases.

Keywords: Neuronal regenerative, stem cell therapy, transplantation therapy.

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Article Details

VOLUME: 9
ISSUE: 1
Year: 2014
Page: [38 - 43]
Pages: 6
DOI: 10.2174/1574362409666140820225940

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