(E)-2-Arylmethylideneindolin-3-ol derivatives have been explored as new and potential anti-proliferative
agents. Synthesis of these compounds was carried out by using a Pd/C-catalyzed alternative and one-pot method involving
C-C coupling of 1-(2-(p-tosylamino)phenyl)prop-2-yn-1-ol with a range of iodoarenes followed by intramolecular hydroamination
in the same pot. The reaction proceeded faster when performed under ultrasound irradiation. All these compounds
showed selective growth inhibition of MDA-MB 231 cancer cells.
Keywords: Cancer, coupling, hydroamination, indolin-3-ol, Pd/C.
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