Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Pd/C-catalyzed Synthesis of (E)-2-arylmethylideneindolin-3-ols Under Ultrasound: Their Initial Evaluation as Potential Anti-proliferative Agents

Author(s): Ponugubati Radhakrishna Murthi, Namburi Suresh, Chekuri Sharmila Rani, Mandava Venkata Basaveswara Rao, Manojit Pal.

Graphical Abstract:


Abstract:

(E)-2-Arylmethylideneindolin-3-ol derivatives have been explored as new and potential anti-proliferative agents. Synthesis of these compounds was carried out by using a Pd/C-catalyzed alternative and one-pot method involving C-C coupling of 1-(2-(p-tosylamino)phenyl)prop-2-yn-1-ol with a range of iodoarenes followed by intramolecular hydroamination in the same pot. The reaction proceeded faster when performed under ultrasound irradiation. All these compounds showed selective growth inhibition of MDA-MB 231 cancer cells.

Keywords: Cancer, coupling, hydroamination, indolin-3-ol, Pd/C.

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Article Details

VOLUME: 12
ISSUE: 2
Year: 2015
Page: [109 - 116]
Pages: 8
DOI: 10.2174/1570180811666140819224103
Price: $58