Inflammation-Mediating Proteases: Structure, Function in (Patho) Physiology and Inhibition
Affiliation: National Institute of Chemistry, Ljubljana, Slovenia; EN→FIST Centre of Excellence, 1000 Ljubljana, Slovenia.
Keywords: ADAMTS, granzymes, inflammation, inhibitors, kallikreins, (patho)physiology, plasmin, proteases.
Proteases regulating inflammation are versatile enzymes, usually extracellular matrix degrading enzymes that
are involved in wound healing, angiogenesis, coagulation, development, apoptosis and other physiological processes.
Their dysregulation and increased expression during inflammation can have devastating consequences, promoting etiology
of vascular diseases, inflammatory arthritis, cancer, and allograft rejection. In this review several proteases
(ADAMTS, granzymes, plasmin, and kallikreins) with different mechanisms and substrates are described in addition to
their physiological roles and contribution to inflammation and inflammatory diseases. Inhibition of proteases may therefore
represent an attractive strategy for treatment and herein we describe physiological and engineered inhibitors.
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