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Current Pharmaceutical Analysis

Editor-in-Chief

ISSN (Print): 1573-4129
ISSN (Online): 1875-676X

Simultaneous Determination of Antidiabetic Thiazolidinediones Using Flow Through Voltammetric Sensor

Author(s): Lai-Hao Wang and Yan-Lin Song

Volume 10, Issue 4, 2014

Page: [239 - 245] Pages: 7

DOI: 10.2174/1573412910666140818215811

Price: $65

Abstract

We developed a method that uses flow through voltammetric sensor to quantitatively determine thiazolidine-2, 4-diones (TZDs) derivatives which are pioglitazone, rosiglitazone and troglitazone. The method uses a gold electrode. The dynamic range for determining thiazolidine-2, 4-diones (TZDs) is extended by more than two orders of magnitude. The quantification limits are 0.10, 23, 15, 0.005 ng for thiazolidine-2, 4-dione, pioglitazone, rosiglitazone and troglitazone, respectively. The method can be applied to the quantitatively determining pioglitazone and rosiglitazone in antidiabetic drugs. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable.

Keywords: Voltammetric sensor, thiazolidine-2, 4-diones (TZDs), antidiabetic drugs.

Graphical Abstract

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