Simultaneous Determination of Antidiabetic Thiazolidinediones Using Flow Through Voltammetric Sensor

Author(s): Lai-Hao Wang, Yan-Lin Song.

Journal Name: Current Pharmaceutical Analysis

Volume 10 , Issue 4 , 2014

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Abstract:

We developed a method that uses flow through voltammetric sensor to quantitatively determine thiazolidine-2, 4-diones (TZDs) derivatives which are pioglitazone, rosiglitazone and troglitazone. The method uses a gold electrode. The dynamic range for determining thiazolidine-2, 4-diones (TZDs) is extended by more than two orders of magnitude. The quantification limits are 0.10, 23, 15, 0.005 ng for thiazolidine-2, 4-dione, pioglitazone, rosiglitazone and troglitazone, respectively. The method can be applied to the quantitatively determining pioglitazone and rosiglitazone in antidiabetic drugs. Findings using high-performance liquid chromatography with a flow-through voltammetric detector and ultraviolet detector are comparable.

Keywords: Voltammetric sensor, thiazolidine-2, 4-diones (TZDs), antidiabetic drugs.

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2014
Page: [239 - 245]
Pages: 7
DOI: 10.2174/1573412910666140818215811
Price: $58

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