The pyrrolidine ring can be found in numerous natural products and in many pharmaceuticals. Hygrine, as an example of a
pyrrolidine alkaloid, is the biosynthetic precursor of pharmacologically important tropane alkaloids. This review summarizes the synthetic
routes toward racemic and enantiopure hygrine.
Keywords: Asymmetric synthesis, hygrine, labeled synthesis, natural products, pyrrolidine alkaloids, total synthesis.
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