Total Syntheses of the Pyrrolidine Alkaloid, Hygrine

Author(s): Matyas Milen, Peter Abranyi-Balogh, Gyorgy Keglevich.

Journal Name: Current Organic Synthesis

Volume 11 , Issue 6 , 2014

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Abstract:

The pyrrolidine ring can be found in numerous natural products and in many pharmaceuticals. Hygrine, as an example of a pyrrolidine alkaloid, is the biosynthetic precursor of pharmacologically important tropane alkaloids. This review summarizes the synthetic routes toward racemic and enantiopure hygrine.

Keywords: Asymmetric synthesis, hygrine, labeled synthesis, natural products, pyrrolidine alkaloids, total synthesis.

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Article Details

VOLUME: 11
ISSUE: 6
Year: 2014
Page: [889 - 901]
Pages: 13
DOI: 10.2174/1570179411666140818210247
Price: $58

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