p42.3: An Abductor of Cell Cycle
As a newly discovered tumor-associated gene, p42.3 was originally ascertained in gastric cancer cell line
BGC823 and has been confirmed as a cell cycle-dependent gene that is overexpressed in many human tumor cell lines and
embryonic tissues. p42.3 can regulate the level of relevant cycle-dependent proteins and promote malignant transformation
of cells. A variety of cellular functions, including cell proliferation, cell invasion and cell migration, are under control of
p42.3. Our review, namely the introduction of the structure of p42.3, underlying activity regulation mechanisms of p42.3 as
well as the role p42.3 plays in malignant cellular transformation process, are accompanied by the presentation of potential
directions of further researches of cancer prevention and therapy in which p42.3 is inevitable.
Keywords: Abductor, cancer, cell cycle, p42.3, STAT5.
Rights & PermissionsPrintExport